In the original Full House, the attic that Becky and Jesse lived in is completely different from the one in this new series. When D.J. shows Ramona her room where Nicky and Alex stayed, it's on the opposite side of the attic and is much smaller than the one in the original show.
 Probably the biggest mistake is the origin of Jimmy Gibbler and why he's never been mentioned before, only her three sisers and an older brother has been previously mentioned of Kimmy's family. Jimmy is suppose to be a few years younger than Kimmy, but Kimmy clearly mentions in a season 3 episode in Full House that she's glad her parents stopped having kids after her.